Calculation of 51Cr‐EDTA clearance in children from the activity in one plasma sample by transformation of the biexponential plasma time‐activity curve into a monoexponential with identical integral area below the time‐activity curve

Publisher Website
Google Scholar
Abstract
Summary. The relation between 51Cr‐EDTA clearance and plasma 51Cr‐activity in children was analysed introducing the functions s(t) and g(t) for transformation of the biexponential plasma time‐activity curve to a monoexponential with identical area below the time‐activity curve. The theory of s(t) and g(t) were discussed and the variation of g(t) with time was determined empirically. The functions s(t) and g (t) were used to derive a formula for the calculation of 51Cr‐EDTA clearance in children from one single plasma sample (ClST) withdrawn between 90 and 150 min after the injection. ClST and 51Cr‐EDTA clearance calculated by means of a standard method were almost identical (r = 0·991). It is concluded that the formula may prove useful for calculation of 51Cr‐EDTA clearance in children.