Transient expression of c-Fos in rat amygdala during training is required for encoding conditioned taste aversion memory.
Open Access
- 1 July 1996
- journal article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 3 (1) , 31-41
- https://doi.org/10.1101/lm.3.1.31
Abstract
Local microinjection into rat amygdala of phosphorothioate modified oligodeoxynucleotides (ODNs) antisense to c-fos several hours before conditioned taste aversion (CTA) training impaired taste aversion memory tested 3-5 days after conditioning. In contrast, injection of the antisense ODNs several days before training, before testing, or into the basal ganglia, or injection of c-fos sense ODNs, had no effect on CTA memory. Inhibition of translation by local microinjection of anisomycin into the amygdala shortly before as well as during CTA training, but not several days before training or shortly before testing, also impaired CTA memory. We conclude that translation in general, and c-Fos translation in particular, in the amygdala during or immediately after CTA training is essential for encoding taste aversion memory.Keywords
This publication has 38 references indexed in Scilit:
- The application of antisense oligonucleotide technology to the brain: Some pitfallsCellular and Molecular Neurobiology, 1994
- c-fos expression in the amygdala:In vivo antisense modulation and role in anxietyCellular and Molecular Neurobiology, 1994
- c-fos antisense generates apomorphine and amphetamine-induced rotationNeuroReport, 1993
- Emotional Memory: In Search of Systems and SynapsesaAnnals of the New York Academy of Sciences, 1993
- Expression of c-fos in brain subcortical structures in response to nauseant lithium chloride and osmotic pressure in ratsNeuroscience Letters, 1993
- Taste memory: The role of protein synthesis in gustatory cortexBehavioral and Neural Biology, 1993
- Antisense oligonucleotide eliminates in vivo expression of c-fos in mammalian brainEuropean Journal of Pharmacology: Molecular Pharmacology, 1992
- Neophobia and conditioned taste aversion deficits in the rat produced by undercutting temporal cortexPhysiology & Behavior, 1983
- Effects of central amygdaloid nucleus lesions on ingestion, taste reactivity, exploration and taste aversionPhysiology & Behavior, 1979
- Taste pathways to hypothalamus and amygdalaJournal of Comparative Neurology, 1976