TECHNETIUM PYROPHOSPHATE SCANNING IN DETECTION OF ACUTE MYOCARDIAL-INFARCTION - CLINICAL EXPERIENCE

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 116  (3) , 260-263
Abstract
Technetium-99m-stannous pyrophosphate (99mTc-PYP) accumulates in acutely infarcted myocardium and can be detected by scintiscanning. The clinical values of 99mTc-PYP scintiscanning was studied in 83 patients 6 h to 21 days after the onset of acute chest pain. In 12 patients with normal ECG and serum enzyme values no uptake of 99mTc-PYP was detected on the scintigrams. Of 44 patients with ECG or enzyme evidence or both, of acute myocardial infarction the scintigrams were positive in 31, questionable in 2 and negative in 11; no positive scan was obtained within 12 h of the onset of pain, and the scans generally remained positive for up to 5 days. In 24 patients with evidence of prolonged myocardial ischemia the scans were positive in 2, questionable in 4 and negative in 18. The scans were negative in each of 3 patients with acute or constrictive pericarditis. Localization by ECG and scintiscanning correlated nearly perfectly for transmural infarcts, but subendocardial infarcts could not always be localized precisely by scintiscanning. The infarct area (total area of 99mTc-PYP uptake) correlated well with the peak serum value of creatine phosphokinase.