Pulmonary Edema with Nifedipine in Primary Pulmonary Hypertension

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Abstract
Vasodilator therapy of primary pulmonary hypertension remains unsatisfactory. Nifedipine, a Ca channel antagonist, was recommended for the treatment of primary pulmonary hypertension. Transient mild side effects to this drug are known. A case of primary pulmonary hypertension is reported in whom oral nifedipine use was followed by fatal pulmonary edema. Nifedipine has the potental of causing life-threatening complications of pulmonary edema in patients with severe primary pulmonary hypertension, and in this condition it should be used cautiously.

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