NALOXONE: DOSE-DEPENDENT ANTAGONISM OF RESPIRATORY DEPRESSION BY FENTANYL IN ANAESTHETIZED PATIENTS
Open Access
- 1 February 1977
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 49 (2) , 151-154
- https://doi.org/10.1093/bja/49.2.151
Abstract
Naloxone was used to antagonize the respiratory depression caused by the administration of fentanyl 0.05 mg to patients anaesthetized with 0.5% halothane in 70% nitrous oxide in oxygen. Four groups of at least 10 patients each were studied. Doses of 0.1, 0.2 and 0.4 mg of naloxone were given, and an effect proportional to the logarithm of the dose was demonstrated.This publication has 2 references indexed in Scilit:
- THE HUMAN PHARMACOLOGY AND ABUSE POTENTIAL OF N-ALLYLNOROXYMORPHONE (NALOXONE)The Journal of Pharmacology and Experimental Therapeutics, 1967
- STUDIES OF ANALGESIC DRUGS .8. NARCOTIC ANTAGONIST ANALGESIC WITHOUT PSYCHOTOMIMETIC EFFECTS1964