Developmental expression of cloned cardiac potassium channels
- 24 June 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 284 (2) , 152-154
- https://doi.org/10.1016/0014-5793(91)80673-q
Abstract
Cardiac K+ channels are responsible for repolarization of the action potential and are the targets of several antiarrhythmic drugs. This study examines the differential expression of six K+ channel mRNAs during rat heart development. RK1 and RK2 K+ channel transcripts were undetectable prior to 10 days after birth. In contrast, RK4 mRNA was present at equivalent levels from day 14 in utero to 20 days after birth. RK3 and RK5 were detected as early as 14 days in utero. These data indicate that K+ channel expression in the heart is closely regulated and further argue for physiologically distinct roles for K+ channel isoformsKeywords
This publication has 9 references indexed in Scilit:
- Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart.Proceedings of the National Academy of Sciences, 1991
- Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brainNeuron, 1990
- Heteromultimeric channels formed by rat brain potassium-channel proteinsNature, 1990
- K + Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and MouseScience, 1990
- A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloningNature, 1989
- Post‐natal development of K+ currents studied in isolated rat pineal cells.The Journal of Physiology, 1989
- Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in DrosophilaNature, 1988
- Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro.Molecular and Cellular Biology, 1984
- Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probesCell, 1980