Functional and Physical Interactions of Components of the Yeast Mitochondrial Inner‐Membrane Import Machinery (MIM)
- 1 August 1995
- journal article
- Published by Wiley in European Journal of Biochemistry
- Vol. 232 (1) , 309-314
- https://doi.org/10.1111/j.1432-1033.1995.tb20813.x
Abstract
The essential mitochondrial inner-membrane protein, Mim44, is involved in the translocation of preproteins across the mitochondrial inner membrane. Two other putative components of this protein-translocation system are the integral inner-membrane proteins, Mim23 and Mim17. Here, we present genetic evidence for functional co-operation of all three proteins. Furthermore, we show that Mim23 and Mim17 are associated in a protein complex that also contains two proteins of 55 kDa and 20 kDa. We speculate that this subcomplex forms the proteinaceous import channel of the inner-membrane which transiently interacts with a less abundant peripheral complex of Mim44 and mitochondrial heat-shock protein Hsp70.Keywords
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