15(S)-15-Methyl-Prostaglandin F2αUsed for Induction of Delivery in the Case of Intra-Uterine Fetal Death

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Abstract
Pregnant women (102) with intrauterine fetal death after the 12th week of gestation were treated with 15(S)-15-methyl-prostaglandin F2.alpha. i.m. with doses of 125-250 .mu.g at 2-3 h intervals. In all cases abortion or delivery was completed within 30 h. The average time in primigravidae was 9 h 43 min in multigravidae 9 h 59 min. In .apprx. 2/3 of the patients, mild or moderate gastrointestinal side effects were recorded in spite of prophylactic treatment with retardin or loperamide + diphenoxylate. The therapy was found to be effective, easy to administer and side effects acceptable. No serious side effects were recorded.