PROSTAGLANDIN-E2 DEPRESSES NATURAL CYTO-TOXICITY BY INHIBITING INTERLEUKIN-1 PRODUCTION BY LARGE GRANULAR LYMPHOCYTES
- 1 January 1984
- journal article
- research article
- Vol. 57 (2) , 380-384
Abstract
Enriched large granular [human] lymphocytes treated with varying concentrations of prostaglandin E2 (PGE2) for varying time periods showed considerably reduced natural cytotoxicity against K-562 [human leukemia] target cells. The same cells when activated by lipopolysaccharide produced substantially less interleukin-1 (IL-1) as compared to cells not treated with PGE2. The inhibition of natural killer (NK) cell activity produced by PGE2 is due to inhibition of IL-1 production by these cells.This publication has 12 references indexed in Scilit:
- The modulation of human natural killer cell activity by prostaglandins.1982
- Antagonistic effects of interferons on the cytotoxicity mediated by natural killer cells.1981
- Inhibition of murine natural killer cell activity by prostaglandins.The Journal of Immunology, 1980
- Prostaglandin E2 rather than lymphocyte-activating factor produced by activated human mononuclear cells stimulates increases in murine thymocyte cAMPCellular Immunology, 1980
- Tumor Growth Inhibition and Potentiation of Immunotherapy by Indomethacin in Mice2JNCI Journal of the National Cancer Institute, 1979
- A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cellsCellular Immunology, 1978
- Prostaglandins from tumours of human large bowelBritish Journal of Cancer, 1977
- The effects of cyclic AMP on leucocyte inhibitory factor (LIF) production and on the inhibition of leucocyte migration.1976
- BREAST CANCER, PROSTAGLANDINS, AND BONE METASTASESThe Lancet, 1975
- Human lymphocyte metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutininJournal of Clinical Investigation, 1971