Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex
- 7 September 2008
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 11 (10) , 1140-1142
- https://doi.org/10.1038/nn.2188
Abstract
There are many mechanisms for LTD, but it remains unknown which one underlies experience-dependent plasticity during development. Wright and colleagues now report that LTD in response to developmental deprivation depends on the GluR1 subunit in barrel cortex layers 2/3 and 4. Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III–V, pathway.Keywords
This publication has 15 references indexed in Scilit:
- Developmental Switch in the Contribution of Presynaptic and Postsynaptic NMDA Receptors to Long-Term DepressionJournal of Neuroscience, 2007
- Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic PlasticityNeuron, 2007
- The Role of Nitric Oxide and GluR1 in Presynaptic and Postsynaptic Components of Neocortical PotentiationJournal of Neuroscience, 2006
- Two Coincidence Detectors for Spike Timing-Dependent Plasticity in Somatosensory CortexJournal of Neuroscience, 2006
- Neocortical LTD via Coincident Activation of Presynaptic NMDA and Cannabinoid ReceptorsNeuron, 2003
- Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivationNature Neuroscience, 2003
- Experience Strengthening Transmission by Driving AMPA Receptors into SynapsesScience, 2003
- Long-term depression induced by sensory deprivation during cortical map plasticity in vivoNature Neuroscience, 2003
- Conditional Restoration of Hippocampal Synaptic Potentiation in GluR-A-Deficient MiceScience, 2001
- Ca 2+ /calmodulin-kinase II enhances channel conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptorsProceedings of the National Academy of Sciences, 1999