Collagen Proline Hydroxylase in Wound Healing, Granuloma Formation, Scurvy, and Growth
- 25 August 1967
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 157 (3791) , 927-929
- https://doi.org/10.1126/science.157.3791.927
Abstract
Compared to homologous tissues from adult animals, rapidly growing embryonic and fetal tissues contain large amounts of collagen proline hydroxylase. Lung and skin from scorbutic guinea pigs contain one-third as much enzyme as normal tissues do. A rapid increase in proline hydroxylase occurs on the 2nd day of formation of granuloma after injection of carrageenan and on the 4th day of wound healing. The increase in enzyme activity is associated with the onset of collagen biosynthesis and deposition.Keywords
This publication has 14 references indexed in Scilit:
- Cofactor and substrate requirements of collagen proline hydroxylaseArchives of Biochemistry and Biophysics, 1967
- Studies in the Healing of Cutaneous WoundsArchives of Surgery, 1966
- A rapid assay for collagen proline hydroxylaseAnalytical Biochemistry, 1966
- The intra‐embryonic and extra‐embryonic distribution of hydroxyproline in the hen's eggJournal of Experimental Zoology, 1966
- Function of Ascorbic Acid in the Conversion of Proline to Collagen HydroxyprolineNature, 1962
- Local Morphological Response Following a Single Subcutaneous Injection of Carrageenin in the RatExperimental Biology and Medicine, 1959
- Connective tissue growth stimulated by carrageenin. 2. The metabolism of sulphated polysaccharidesBiochemical Journal, 1957
- Connective tissue growth stimulated by carrageenin. 1. The formation and removal of collagenBiochemical Journal, 1957
- Chemical and Histochemical Sequences in the Normal Healing of WoundsNew England Journal of Medicine, 1955
- Hydroxyproline Content of the Developing Chick EmbryoExperimental Biology and Medicine, 1950