Electrophysiological approach to the action of taurine on rat gastric mucosa.

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Abstract
The effect of taurine on isolated rat gastric mucosa was examined electrophysiologically to clarify the mechanism of taurine-induced effect on drug absorption. Although taurine itself had little effect on the electrical parameters, potential difference (PD), short-circuit current (ISC) and tissue resistance (R), of the gastric mucosa, sodium lauryl sulfate, an anionic surfactant, reduced these parameters remarkably. When aspirin was present, taurine showed different effects on the gastric mucosa, depending on the concentrations of aspirin. Taurine decreased ISC significantly in the presence of aspirin at low concentration (1 mM), which has in itself no influence on the electric parameters. Aspirin at higher concentration (10 mM) acted as a barrier breaker of the gastric mucosa resulting in a marked decline of PD and ISC. When taurine was added, these parameters were reasonably recovered. Apparently, taurine acts as a protector against the aspirin-induced damage in the gastric mucosa.

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