STUDIES ON THE BLOOD PLASMA CALCIUM OF NORMAL AND PARATHYROIDECTOMIZED ALBINO RATS

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Abstract
The blood plasma Ca of non-fasting albino rats on the diet described usually varied between 9.25 and 12.5 mgm. per 100 cc. Unilateral parathyroidectomy did not appreciably change this value. Upon removal of the second parathyroid a temporary drop below a low normal occurred, but persisted for only a few weeks. Following bilateral parathyroidectomy a rapid drop in blood plasma Ca to values between 5 and 8 mgm. per 100 cc. may occur, within 24 hrs., or it may decrease more slowly, requiring from 1 to 10 days to attain such values. A definite tendency for the Ca to rise is manifested by the end of 100 days, and by the end of 200 to 300 days it may have attained a value just below a low normal. The reaction of normal and parathyroidectomized rats to comparable amounts of parathyroid hormone has shown the latter to be 2 to 3 times more reactive.

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