Evidence That Thymocytes Require at Least Two Distinct Signals to Proliferate
Open Access
- 1 December 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 123 (6) , 2890-2893
- https://doi.org/10.4049/jimmunol.123.6.2890
Abstract
Optimal receptivity of thymocytes to the mitogenic stimulus in macrophage culture fluid (MCF) is limited to the time in culture when these cells are spontaneously proliferating. By providing a brief, nonmitogenic lectin pulse, nonproliferating cells can be “activated” and their ability to respond to MCF totally restored. This procedure provides a model system for evaluating thymocyte proliferation and, in particular, the mechanism of action of MCF.This publication has 7 references indexed in Scilit:
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