Buccal uptake, urinary excretion, and physicochemical properties of zipeprol and its N‐dealkylated products
- 1 July 1982
- journal article
- research article
- Published by Wiley in Biopharmaceutics & Drug Disposition
- Vol. 3 (3) , 203-209
- https://doi.org/10.1002/bdd.2510030303
Abstract
Buccal uptake, partition characteristics, ionization constants, and urinary excretion were studied for zipeprol and two of its metabolities. Buccal uptake, measured in a single subject, was found to be correlated with n-heptane/water (ph 7.4) partition values of the compounds, and with proportional excreation of the unchanged drug. The importance of the shape of buccal uptake-pH curves in the prediction of absorption and excretion of these compounds is discussed.Keywords
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