ADAM-33Surfaces as an Asthma Gene
- 19 September 2002
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 347 (12) , 936-938
- https://doi.org/10.1056/nejmcibr022144
Abstract
A recent study identified ADAM-33 as an asthma gene. ADAMs are a subfamily of metalloproteinases, originally identified as proteins on the cell surface, that have two functional domains, a disintegrin and a metalloprotease domain (hence, the acronym ADAM). The authors speculate on the ways in which an excess or deficiency of ADAM-33 could result in the expression of the asthma phenotype.Keywords
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