The conformation of eight-membered 3,2′-O-isopropylidene acetals of some common disaccharides

Abstract
The conformation of the eight-membered 3,2′-O-isopropylidene acetals from methyl β-cellobioside, benzyl β-lactoside, and methyl β-maltoside has been investigated using 1H and 13C n.m.r. spectroscopy and molecular-mechanics calculations. The interglycosidic eight-membered rings strongly restrict the conformational mobility around the glycosidic bond.