Preferential Reduction of Conjugated Bilirubin to Urobilinogen by Normal Fecal Flora.

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Abstract
Summary and Conclusions 1. A method of preparing a relatively stable concentrated adsorbate of conjugated bilirubin (glucuronide) from bile, is described. This has been used in a series of experiments in broth cultures of fecal bacteria. 2. A significant and often much greater increase of urobilinogen formation was observed after addition of the conjugated as contrasted with free bilirubin. 3. The urobilinogen group formed in the bacterial cultures consisted of varying proportions of d-Dehydrourobilin, i-Urobilin, and l-Stercobilin. Under the same conditions the fecal flora readily reduced d-DU to i-U, and i-U to l-S.

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