A 7-Hydroxymethyl Sulfate Ester as an Active Metabolite of 7,12-Dimethylbenz[ a ]anthracene
- 22 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4531) , 403-405
- https://doi.org/10.1126/science.6800033
Abstract
7-Hydroxymethyl-12-methylbenz[alpha]anthracene (7-HMBA), a carcinogenic major metabolite of 7,12-dimethylbenz[alpha]anthracene (DMBA) in liver, was transformed by liver cytosolic sulfotransferase to reactive 7-HMBA sulfate, which is mutagenic toward Salmonella typhimurium strain TA98. The mutagenicity of 7-HMBA in the presence of hepatic sulfotransferase was much higher than that of DMBA or 7-HMBA in the presence of hepatic monooxygenase.This publication has 16 references indexed in Scilit:
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