THE EFFECTS OF ANOXEMIA DUE TO CARBON MONOXIDE AND LOW OXYGEN ON CEREBROSPINAL FLUID PRESSURE

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Abstract
Expts. are reported in which exposure of cats to 0.5% CO and to 6.0 and 8.0% O2 resulted without exception in increased cerebrospinal fluid pressure. The avg. increase during CO exposure was 1.74 times the normal. The increases during 6.0 and 8.0% O2 were 1.5 and 1.1 times the normal, respectively. The immediate increases in cerebrospinal fluid pressure are believed due to increased cerebral blood pressure, since the change occurs before the blood O2 saturation is effectively lowered. The secondary increase and the prolonged elevation of cerebrospinal fluid pressure is believed due to accumulation of fluid from the cerebral capillaries, whose permeability is increased when blood O2 saturation is effectively lowered. The O2 saturation during the secondary pressure increase averages 41%, and at the time of maximum pressure avgs. 35%.