Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex
- 2 July 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 285 (5424) , 93-96
- https://doi.org/10.1126/science.285.5424.93
Abstract
Regulation of N-methyl-d-aspartate (NMDA) receptor activity by kinases and phosphatases contributes to the modulation of synaptic transmission. Targeting of these enzymes near the substrate is proposed to enhance phosphorylation-dependent modulation. Yotiao, an NMDA receptor–associated protein, bound the type I protein phosphatase (PP1) and the adenosine 3′,5′-monophosphate (cAMP)–dependent protein kinase (PKA) holoenzyme. Anchored PP1 was active, limiting channel activity, whereas PKA activation overcame constitutive PP1 activity and conferred rapid enhancement of NMDA receptor currents. Hence, yotiao is a scaffold protein that physically attaches PP1 and PKA to NMDA receptors to regulate channel activity.Keywords
This publication has 44 references indexed in Scilit:
- AKAP350, a Multiply Spliced Protein Kinase A-anchoring Protein Associated with CentrosomesJournal of Biological Chemistry, 1999
- Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1The EMBO Journal, 1997
- PTG, a Protein Phosphatase 1-Binding Protein with a Role in Glycogen MetabolismScience, 1997
- Identification of Protein‐Phosphatase‐1‐Binding Domains on the Glycogen and Myofibrillar Targetting SubunitsEuropean Journal of Biochemistry, 1996
- Regulated Subcellular Distribution of the NR1 Subunit of the NMDA ReceptorScience, 1995
- Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal TransductionScience, 1995
- Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2ANature, 1994
- Regulation of NMDA channel function by endogenous Ca2+-dependent phosphataseNature, 1994
- Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neuronsNature, 1994
- Calcium-induced actin depolymerization reduces NMDA channel activityPublished by Elsevier ,1993