2-Substituted azole derivatives. 1. Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles
- 1 July 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (7) , 734-738
- https://doi.org/10.1021/jm00181a007
Abstract
A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole (6) was studied. A comparison of compound 6 with phenylbutazone and tiaramide revealed that 6 has stronger activity in acute inflammatory models, possibly with slightly less gastrointestinal irritation than phenylbutazone and tiaramide.This publication has 4 references indexed in Scilit:
- The mode of action of tiaramide hydrochloride: A new antiasthmatic drugPharmacological Research Communications, 1979
- 2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agentsJournal of Medicinal Chemistry, 1978
- Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory DrugsExperimental Biology and Medicine, 1962
- PHARMACOLOGICAL STUDIES OF 1,2-DIMETHYL-3-PHENYL-3-PROPIONOXYPYRROLIDINE (CI-427), AN ANALGETIC AGENT1961