BE-14348 substances, new specific estrogen-receptor binding inhibitors. Production, isolation, structure determination and biological properties.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (12) , 1533-1542
- https://doi.org/10.7164/antibiotics.43.1533
Abstract
Streptomyces graminofaciens BA14348, isolated from a soil sample, was found to produce new specific inhibitors of estrogen binding to its receptor. Five related substances, BE-14348A-E, were isolated, and their structures were determined by analyses of spectral properties. Of these substances, A was identical with the known flavanone, naringenin. On the other hand, B, C, D and E were all new compounds; the structure of B was determined to be 2(S):3(S)-3-methyl-4', 5, 7-trihydroxyflavanone, C was a racemic mixture of 2(S):3(R) and 2(R):3(S)-3-methyl-4', 5, 7-trihydroxyflavanone; D and E were 8-chloro derivatives of B and C, respectively.This publication has 2 references indexed in Scilit:
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