Reduction by a Model of NAD(P)H. 28. Reduction of an α-Diketone in the Presence of Zinc Ion
- 1 November 1980
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 53 (11) , 3244-3247
- https://doi.org/10.1246/bcsj.53.3244
Abstract
Reduction of 1-phenyl-2-(2-pyridyl)-1,2-ethanedione with 1-benzyl-1,4-dihydronicotinamide in acetonitrile in the presence of zinc perchlorate has been studied. The α-diketone coordinates onto zinc ion through its pyridine-ring nitrogen and benzene-side carbonyl oxygen, whereas the reduction takes place on pyridine-side carbonyl group. It is concluded that an effective ligand to a metal ion is not necessarily a facile substrate of the reduction.Keywords
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