Rolipram versus lmipramine in Inpatients with Major, ???Minor??? or Atypical Depressive Disorder: A Double-Blind Double-Dummy Study Aimed at Testing a Novel Therapeutic Approach
- 1 July 1988
- journal article
- clinical trial
- Published by Wolters Kluwer Health in International Clinical Psychopharmacology
- Vol. 3 (3) , 245-253
- https://doi.org/10.1097/00004850-198807000-00006
Abstract
Unlike conventional antidepressants, rolipram stimulates both the presynaptic as well as the postsynaptic component of monoaminergic transmission. Several double-blind comparative trials are on the way to assess the clinical efficacy and safety of this novel compound. The present study was a randomized double-blind double-dummy comparison with imipramine in inpatients with major, "minor" and atypical depressions (DSM III). Results show no relevant differences between rolipram and imipramine regarding efficacy and safety.Keywords
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