A New Synthesis of Lysergic Acid
- 10 December 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (1) , 3-5
- https://doi.org/10.1021/ol0354369
Abstract
(±)-Lysergic acid (1) has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.Keywords
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