Platelet Adhesiveness in von Willebrand’s Disease

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Abstract
A glass bead test for platelet adhesiveness is described in which heparinized blood can be used. Anticoagulation allows the blood to be handled more conveniently and, furthermore, the flow rate can be exactly controlled. By means of this test, decreased platelet adhesiveness has been demonstrated in von Willebrand’s disease, and the difference between von Willebrand’s disease and normal is much greater than that demonstrated by the Salzman test. Evidence is presented to suggest that the abnormality is due to the absence of a plasmatic factor.

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