High levels of cervical HIV-1 RNA during early HIV-1 infection
- 28 November 2006
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 20 (18) , 2389-2390
- https://doi.org/10.1097/qad.0b013e328010f1e7
Abstract
Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition and at viral setpoint (4–24 months). Cervical HIV-1 was higher in early compared with setpoint samples (mean 3.43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006).Keywords
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