MONOSODIUM THYROXINE, DESICCATED THYROID AND AN IMPURE SODIUM SALT OF THYROXINE
- 1 October 1933
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. 52 (4) , 576-592
- https://doi.org/10.1001/archinte.1933.00160040082004
Abstract
In 1926 we gave some Squibb's thyroxine for oral use to two patients with low basal metabolism for a few days in doses of from 2 to 10 mg. daily and, having observed no effect, were content to conclude that the current opinion about its lack of effect when administered by mouth was correct. However, as time went on, it seemed worth while to give the matter more serious study. A review of the literature reveals some difference of opinion as to whether or not thyroxine is effective when administered by mouth. Swingle, Helff and Zwemer,1 by observing the weight and pulse rate, Burmeister,2 by observing the weight and urinary output, and Abelin,3 Schneider,4 and Boller and Högler5 (Schering's thyroxine), on the basis of determinations of basal metabolism, concluded that thyroxine is virtually without effect when administered by mouth to normal human beings. Weiss6 observed no effect in some casesThis publication has 0 references indexed in Scilit: