Prostaglandins and congeners. 22. Synthesis of 11-substituted derivatives of 11-deoxyprostaglandins E1 and E2. Potential bronchodilators
- 1 August 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (8) , 903-913
- https://doi.org/10.1021/jm00182a018
Abstract
The interesting bronchodilator activity of l-11-deoxy-11.alpha.-[(2-hydroxyethyl)thio]prostaglandin E2 methyl ester (3a) in guinea pigs is described. The preparation of 3a and its analogs by Michael-type additions to various members of the PG[prostaglandin]A series or by total synthesis using the lithiocuprate conjugate addition process is also described. Structure-activity relationships in this series are discussed.This publication has 2 references indexed in Scilit:
- Prostaglandins and congeners. 21. Synthesis of some cyclohexyl analogs (11.alpha.-homoprostaglandins)The Journal of Organic Chemistry, 1979
- The effect of prostaglandin E1 on isolated bronchial muscle from manJournal of Pharmacy and Pharmacology, 1968