Delayed Inducibility of Sulphite Reductase in cysM Mutants of Salmonella typhimurium Under Anaerobic Conditions

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Abstract
S. typhimurium cysM mutants grow at a normal rate under aerobic conditions, but only after a lag period under anaerobic conditions. No difference in the induction of 2 cysteine biosynthetic enzymes, sulfite reductase and O-acetyl-L-serine sulfhydrylase, in wild-type, cysK and cysM strains was observed under aerobic conditions. Under anaerobic conditions, however, the cysM strain differed from the others in showing a long delay in the induction of sulfite reductase. These observations are consistent with the assumption that the observed growth delay of the cysM mutant under anaerobic conditions is the result of abnormalities in the regulation of sulfite reductase.