TREATMENT OF PREINVASIVE DISEASE OF THE CERVIX BY CONE BIOPSY

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Abstract
During 1952-1977, 646 patients with abnormal cervical cytology underwent cone biopsy (595) or ring biopsy of the cervix. The histological diagnoses were invasive carcinoma in 20 (3%), microinvasive carcinoma in 16 (2%), carcinoma in situ and severe dysplasia in 418 (65%) and other dysplasias in 149 (23%). The remainder, 43 (7%), had no demonstrable abnormality. Following biopsy, 41 (7%) patients with noninvasive disease had abnormal cytology within 1 yr of biopsy. A further 12 (2%) developed abnormal cytology after 1 yr. These recurrences occurred up to 12 yr after the initial treatment; in 1 patient invasive squamous carcinoma has developed.

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