Remarkable 1,6-Acyclic Diastereoselection in the Coupling of a Novel Butadienyl Di-indium Compound with Aldehydes
- 7 February 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (9) , 2412-2413
- https://doi.org/10.1021/ja0295467
Abstract
The reaction between a novel butadienyl di-indium reagent and aldehydes showed remarkable 1,6-diastereoselectivity to give acetylenic diol products as a single diastereomer. A bicyclic transition state formed through intramolecular chelation control was proposed that might account for the high 1,6-diastereoselection result.Keywords
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