Changes of platelet phospholipids in diabetes mellitus

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Abstract
Summary In the present study the phospholipid and fatty acid concentration of platelets has been measured in patients with poorly and well controlled diabetes mellitus and in control subjects. An increased phosphatidylethanolamine (p < 0.01) and phosphatidylserine (p < 0.001) content of platelets was found in poorly controlled diabetes as well as an increased phosphatidylserine (p < 0.001) concentration in well controlled diabetes. The most notable changes of platelet fatty acids were a decreased concentration of palmitic (16∶0; p < 0.01) and linoleic acid (18∶2; p < 0.001) in the poorly controlled diabetes as well as (p < 0.001) and (p < 0.025) in the well controlled diabetes, respectively. Also, an increased concentration of arachidonic acid (20∶4; p < 0.001) was found in both groups of diabetics. No differences were found in phospholipid concentration between patients with and without vascular diseases.