THE BLOCKADE OF LH RELEASE BY INDOMETHACIN12
- 1 August 1974
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 39 (2) , 399-402
- https://doi.org/10.1210/jcem-39-2-399
Abstract
Indomethacin, a known inhibitor of prostaglandin (PG) synthesis, blocked the estradiol-17β (E2-17β)-induced release of luteinizing hormone (LH) in sheep. This finding provides evidence of an obligatory role for endogenous PG synthesis in the mechanism of LH release. In addition it suggests a possible use for PG inhibitors in fertility control through the blockade of LH release and hence ovulation.Keywords
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