Kidney antigens active in isoimmunization. I. The antigenic diversity.

  • 1 November 1969
    • journal article
    • Vol. 17  (5) , 641-52
Abstract
Isoimmunization of rabbits with kidney extracts and Freund's adjuvant leads to the development of responses to a multiplicity of autoantigens. If a large number of kidneys is pooled, there is increased probability that responses directed toward isoantigens can also be detected. Such immunization thus results largely in antisera that possess multiple specificities, but the amount of antibody directed toward each specific antigen varies from one antiserum to another.