Novel, diastereoselective synthesis of 3‐amino‐1‐alkanols
- 12 February 1990
- journal article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1990 (2) , 211-212
- https://doi.org/10.1002/jlac.199019900138
Abstract
Benzaldehyde adds to 1‐pyrrolidinylcyclohexene under mild conditions giving the amino ketone 3a. The unstable ketone was reduced to the epimeric alcohols 4 and 5, the stereochemistry of which was determined by 2D‐NMR correlation spectroscopy.Keywords
This publication has 4 references indexed in Scilit:
- N,O‐heterocycles, 24. Novel approach to the ring‐opening reaction of isoxazolidinium salts to 1,3‐amino alcoholsEuropean Journal of Inorganic Chemistry, 1988
- A potent benzylamine analgesic:(−)cis-2(α-dimethylamino-m-hydroxybenzyl)cyclohexanolCellular and Molecular Life Sciences, 1978
- Lithium tri-sec-butylborohydride. New reagent for the reduction of cyclic and bicyclic ketones with super stereoselectivity. Remarkably simple and practical procedure for the conversion of ketones to alcohols in exceptionally high stereochemical purityJournal of the American Chemical Society, 1972
- The Addition of Secondary Amines to Some α-Benzal KetonesJournal of the American Chemical Society, 1955