Molecular Graphics: Application to the Structure Determination of a Snake Venom Neurotoxin
- 30 September 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4311) , 1378-1381
- https://doi.org/10.1126/science.897675
Abstract
Atomic coordinates have been determined for a snake venom alpha-neurotoxic protein by fitting a molecular model to a crystallographically derived 2.2-angstrom electron density map. The fitting was carried out entirely on a computer-operated molecular, graphics system without going through any mechanical model stage.Keywords
This publication has 14 references indexed in Scilit:
- The crystal structure of a post‐synaptic neurotoxin from sea snake at 2.2 Å resolutionFEBS Letters, 1976
- Computer manipulation of (macro)molecules with the method of local changeActa Crystallographica Section A, 1974
- A Model Of The Three‐Dimensional Structure Of Snake Venom Neurotoxins Based On Chemical EvidenceInternational Journal of Peptide and Protein Research, 1973
- Neurotoxins of Animal Venoms: SnakesAnnual Review of Biochemistry, 1973
- Interactive Computer Graphics and Representation of Complex Biological StructuresAnnual Review of Biophysics and Bioengineering, 1972
- Refinement of X-ray data on proteins. I. Adjustment of atomic coordinates to conform to a specified geometryJournal of Computational Physics, 1972
- Chemistry and Pharmacology of Polypeptide Toxins in Snake VenomsAnnual Review of Pharmacology, 1972
- Characterization and chemical modifications of toxins isolated from the venoms of the sea snake, Laticauda semifasciata, from PhilippinesBiochemistry, 1971
- The matching of physical models to three-dimensional electron-density maps: A simple optical deviceJournal of Molecular Biology, 1968
- A mathematical model-building procedure for proteinsActa Crystallographica, 1966