A 3H-Flunitrazepam Binding Inhibitor is Present in Psychiatric Patients’ Sera
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 18 (2) , 74-76
- https://doi.org/10.1159/000118396
Abstract
We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-flunitrazepam binding specifically in the samples taken from the patients'' groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.This publication has 4 references indexed in Scilit:
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