MAPK signalling: ERK5 versus ERK1/2
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Open Access
- 1 August 2006
- journal article
- review article
- Published by Springer Nature in EMBO Reports
- Vol. 7 (8) , 782-786
- https://doi.org/10.1038/sj.embor.7400755
Abstract
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation motif. Both ERK5 and ERK1/2 are activated by growth factors and have an important role in the regulation of cell proliferation and cell differentiation. Moreover, both the ERK5 and the ERK1/2 pathways are sensitive to PD98059 and U0126, which are two well‐known inhibitors of the ERK pathway. Despite these similarities, recent studies have revealed distinctive features of the ERK5 pathway: ERK5 has a key role in cardiovascular development and neural differentiation; ERK5 nuclear translocation is controlled by its own nuclear localizing and nuclear export activities; and the carboxy‐terminal half of ERK5, which follows its kinase catalytic domain, has a unique function.Keywords
This publication has 74 references indexed in Scilit:
- Cyclic AMP Selectively Uncouples Mitogen-Activated Protein Kinase Cascades from Activating SignalsMolecular and Cellular Biology, 2006
- Both Nuclear-Cytoplasmic Shuttling of the Dual Specificity Phosphatase MKP-3 and Its Ability to Anchor MAP Kinase in the Cytoplasm Are Mediated by a Conserved Nuclear Export SignalJournal of Biological Chemistry, 2004
- Neural Induction in Xenopus: Requirement for Ectodermal and Endomesodermal Signals via Chordin, Noggin, β-Catenin, and CerberusPLoS Biology, 2004
- The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required InteractionsJournal of Biological Chemistry, 2004
- Activation of cyclin D1 expression by the ERK5 cascadeOncogene, 2003
- ERK5 and ERK2 Cooperate to Regulate NF-κB and Cell TransformationJournal of Biological Chemistry, 2001
- Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout MiceScience, 1999
- Identification of Substrates and Regulators of the Mitogen-activated Protein Kinase ERK5 Using Chimeric Protein KinasesJournal of Biological Chemistry, 1998
- Primary Structure of BMK1: A New Mammalian MAP KinaseBiochemical and Biophysical Research Communications, 1995
- The MAP kinase cascade is essential for diverse signal transduction pathwaysTrends in Biochemical Sciences, 1993