Silica gel functionalized with amino groups is a useful insoluble catalyst for the Knoevenagel condensation: the reaction can be carried out under continuous-flow conditions and good yields are obtained when aromatic aldehydes, cyclohexanone, and acetophenone react with ethyl acetoacetate, ethyl cyanoacetate, and malononitrile. Lower yields are obtained in the case of ethyl benzoylacetate and acetylacetone; this fact and the easy dehydration of the aldol intermediate strongly suggest the participation of the residual free silanol groups of the matrix in the catalysis mechanism.