The effects of pre-incubation period and norharman on the mutagenic potency of 4-dimethylaminoazobenzene and 3′-methyl-4-dimethylaminoazobenzene in S. typhimurium

Publisher Website
Google Scholar
Abstract
The effects of the co-mutagen norharman on the mutagenicity of the rodent liver carcinogens 4-dimethyl-aminoazobenzene (DAB) and 3′-methyl-4-dimethyl-aminoazobenzene (3′MeDAB) have been evaluated using the Ames Salmonella mutation assay. A period of pre-incubation was found to be necessary in order to detect DAB as a mutagen and to increase the initially weak response observed for 3′MeDAB; maximum responses were seen after 1 h pre-incubatlon in each case. The co-mutagenic properties of norharman were at their maximum for both azo-dyes in the direct plate-incorporation assay. Pre-incubation of either compound with norharman for increasing periods of time resulted in a decrease in potentiation, until after 1 h, an inhibition of mutagenicity was observed.

This publication has 9 references indexed in Scilit: