Formulation of Long-Acting Quinacrine Hydrochloride Pellets in Different Matrices I

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Abstract
In this study, quinacrine hydrochloride, which is a very soluble drug in water was selected as the active ingredient to formulate a long-acting dosage form. The prolonged release form is obtained by incorporating the drug in an inert solid matrix. Since it is believed that if the correct matrix and hardness is chosen the drug release can be controlled. The effect of different fatty acids, fatty alcohols, polymers and waxes individually or in combinations were investigated.