Destroying Gadofullerene Aggregates by Salt Addition in Aqueous Solution of Gd@C60(OH)x and Gd@C60[C(COOH2)]10
- 9 June 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (26) , 9368-9369
- https://doi.org/10.1021/ja052388+
Abstract
A combined proton relaxivity and dynamic light scattering study has shown that aggregates formed in aqueous solution of water-soluble gadofullerenes can be disrupted by addition of salts. The salt content of fullerene-based materials will strongly influence properties related to aggregation phenomena, therefore, their behavior in biological or medical applications. In particular, the relaxivity of gadofullerenes decreases dramatically with phosphate addition. Moreover, real biological fluids present a rather high salt concentration which will have consequences on fullerene aggregation and influence fullerene-based drug delivery.Keywords
This publication has 15 references indexed in Scilit:
- Water-Soluble Gadofullerenes: Toward High-Relaxivity, pH-Responsive MRI Contrast AgentsJournal of the American Chemical Society, 2004
- Active Oxygen Species Generated from Photoexcited Fullerene (C60) as Potential Medicines: O2-•versus1O2Journal of the American Chemical Society, 2003
- First Soluble M@C60 Derivatives Provide Enhanced Access to Metallofullerenes and Permit in Vivo Evaluation of Gd@C60[C(COOH)2]10 as a MRI Contrast AgentJournal of the American Chemical Society, 2003
- Lanthanoid Endohedral Metallofullerenols for MRI Contrast AgentsJournal of the American Chemical Society, 2003
- From monomers to micelles: investigation of the parameters influencing proton relaxivityJBIC Journal of Biological Inorganic Chemistry, 2002
- Synthesis and In vitro characterization of a tissue-Selective fullerene: vectoring C60(OH)16AMBP to mineralized boneBioorganic & Medicinal Chemistry, 2002
- Toward fullerene-based radiopharmaceuticals: high-yield neutron activation of endohedral 165Ho metallofullerenesChemical Physics Letters, 1999
- Spectroscopic Studies of Fullerene AggregatesThe Journal of Physical Chemistry A, 1998
- Synthesis and Solvent Enhanced Relaxation Property of Water-Soluble Endohedral MetallofullerenolsFullerene Science and Technology, 1997
- Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verificationJournal of the American Chemical Society, 1993