Conformational stability of alternating d (CG) oligomers in high salt solution
- 1 January 1981
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 9 (9) , 2195-2206
- https://doi.org/10.1093/nar/9.9.2195
Abstract
The conformation of d (CG)n oligomers with n = 2,3 has been studied in aqueous solution in the presence of high salt concentration. A minimum n value of three is necessary to obtain a left-handed Z-helix. When d (CG)3 is flanked by three non Z-helicogenic alternating AT sequences the left-handed helix is unstable and a B-type conformation is obtained also at high salt concentration.Keywords
This publication has 11 references indexed in Scilit:
- Left-Handed Double Helical DNA: Variations in the Backbone ConformationScience, 1981
- Crystal structure analysis of a complete turn of B-DNANature, 1980
- High-salt d(CpGpCpG), a left-handed Z′ DNA double helixNature, 1980
- The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.Proceedings of the National Academy of Sciences, 1980
- DNA-like duplexes with repetitions. I. Properties of concatemer duplexes formed by d(T-G-C-A-C-A-T-G)Nucleic Acids Research, 1980
- Molecular structure of a left-handed double helical DNA fragment at atomic resolutionNature, 1979
- A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor proteinJournal of Molecular Biology, 1979
- Chemical synthesis of genes for human insulin.Proceedings of the National Academy of Sciences, 1978
- Polymorphism of a synthetic DNA in solutionNature, 1976
- Salt-induced co-operative conformational change of a synthetic DNA: Equilibrium and kinetic studies with poly(dG-dC)Journal of Molecular Biology, 1972