Subchronic Oral Toxicity, Tissue Distribution and Clearance of Hexachloroethane in the Rat

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Abstract
Hexachloroethane (HCE) was fed to Fischer 344 rats at approximate doses of 0, 1, 15 or 62 mg/kg per day for 16 wk. Selected tissues were assayed at termination for HCE content. Histopathological examination identified the kidney as the primary target organ with male rats being more sensitive. The kidney concentration of HCE increased proportionately with dose in the males, but there were disproportionately small increases with dose in females. A group of male rats was given 62 mg/kg per day for 8 wk to estimate tissue clearance. Clearance of HCE from fat, liver, kidney and blood occurred in an apparent 1st-order manner with a half-life of .apprx. 2.5 days. The apparent 1st-order elimination suggested that HCE metabolism and excretion were not saturated in rats given up to 62 mg/kg per day and in the range of doses given, toxicity should have been proportional to exposure concentration. The no-observable-effect level (NOEL) for toxicity was 1 mg/kg per day for male and female rats.

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