Evidence for a Unique in Situ Component of the Repair of Radiation Damage

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Abstract
The survival of rat mammary gland cells irradiated in situ and allowed to remain in situ for 24 h before assay by an in vivo transplantation method was assayed. The D0 [mean lethal dose] was 122 rad, the N [extrapolation number] value was 23, and the Dq [quasi-threshold dose] was 383 rad. When these parameters are compared to those of tissue that was removed immediately after irradiation, the former has a greater N and Dq but no significant difference in D0. Evidence is presented that these differences are due to a unique in situ form of the repair of potentially lethal radiation damage that was termed in situ repair.

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