Neurotransmitter Synthesis by Neuroblastoma Clones
Open Access
- 1 January 1972
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (1) , 258-263
- https://doi.org/10.1073/pnas.69.1.258
Abstract
Neuroblastoma clones were examined for choline acetyltransferase (EC 2.3.1.6), tyrosine hydroxylase (EC 1.14.3.a), acetylcholinesterase (EC 3.1.1.7), and also for neurite formation. One clone does not form axons or dendrites. Three types of clones were found with respect to neurotransmitter synthesis: cholinergic, adrenergic, and clones that do not synthesize acetylcholine or catechols. All clones contain acetylcholinesterase. These results show that genes determining neurotransmitter species can be expressed in dividing cells, that the parental programs of gene expression are inherited, and that dividing cells can be programmed with respect to their ability to communicate with other cells.Keywords
This publication has 14 references indexed in Scilit:
- Regulation of Acetylcholinesterase in Neuroblastoma CellsProceedings of the National Academy of Sciences, 1970
- Regulation of Axon Formation by Clonal Lines of a Neural TumorProceedings of the National Academy of Sciences, 1970
- Isolation of Microtubule Protein from Cultured Mouse Neuroblastoma CellsProceedings of the National Academy of Sciences, 1970
- NEURONAL TUMOR CELLS WITH EXCITABLE MEMBRANES GROWN in vitroProceedings of the National Academy of Sciences, 1969
- In vitro DIFFERENTIATION OF A MOUSE NEUROBLASTOMAProceedings of the National Academy of Sciences, 1969
- ESTABLISHMENT OF FUNCTIONAL CLONAL LINES OF NEURONS FROM MOUSE NEUROBLASTOMAProceedings of the National Academy of Sciences, 1969
- Catecholamine biosynthesis in vivo: An application of thin-layer chromatographyBiochemical Pharmacology, 1965
- A rapid and simple radioassay for tyrosine hydroxylase activityAnalytical Biochemistry, 1964
- IMMUNOSELECTION OF POLYPLOIDS FROM PREDOMINANTLY DIPLOID CELL POPULATIONSAnnals of the New York Academy of Sciences, 1956
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951