Identification of urinary metabolites of 2,4-dinitrotoluene (2,4-DNT) in rats.

1 January 1981

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 29 (4) , 1147-1150
https://doi.org/10.1248/cpb.29.1147

Abstract

Metabolites of 2,4-dinitrotoluene (2,4-DNT) in urine were detected by TLC after repeated oral administration to male Wistar rats. These metabolites, 2-amino-4-nitrotoluene, 4-amino-2-nitrotoluene, 2,4-diaminotoluene, 2,4-dinitrobenzyl alcohol, 2-amino-4-nitrobenzyl alcohol, 4-amino-2-nitrobenzyl alcohol, 2-nitro-4-acetylaminotoluene, 2-amino-4-acetylaminotoluene and 2-amino-4-acetylaminobenzoic acid, were identified by comparison of UV and mass spectral data with those of authentic samples. The probable metabolism of 2,4-DNT in rats was discussed.

This publication has 0 references indexed in Scilit: