GENETICS OF KIDNEY ALLOGRAFT SURVIVAL IN DOGS I. RELEVANCE OF SUBREGIONS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN RECIPIENTS WITHOUT IMMUNOSUPPRESSIVE THERAPY
- 1 September 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 28 (3) , 186-190
- https://doi.org/10.1097/00007890-197909000-00006
Abstract
The influence of subregions of the canine major histocompatibility complex (MHC) on renal allograft survival is assessed in recipients without immunosuppressive therapy. Results in 6 beagle littermate donor-recipient pairs in which the donor or recipient had a recombination in the MHC are compatible with the concept of a predominant role for the subregion containing the major mixed lymphocyte reaction (MLR) locus in determining allograft survival. Results in unrelated mongrel dogs indicate that compatibility for MLR induces a longer kidney allograft survival than compatibility for the serologically defined (SD) antigens. The effect of combined matching for MLR and SD antigens in unrelated donor-recipient pairs is slight in comparison to the effect of MLR and/or SD matching in littermate-related dogs. Other important histocompatibility systems probably exist in this species.Keywords
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